I played with the settings on my Nook, turning the background to sepia (you can also turn it gray so it looks Kindle-like). I read about half a Susan Donovan novel yesterday. I still had some eyestrain, but it wasn't as bad as it was the first day, so I guess less contrast helps. I'm still not sure I'd want to read novels off the device all the time, though.
Also, I've gotten better at turning pages, but I still occasionally can't get the page to turn. I haven't frozen it up again, however.